The 500 Years of Resistance Comic Book is a powerful and historically accurate graphic portrayal of Indigenous resistance to the European colonization of the Americas, beginning with the Spanish invasion under Christopher Columbus and ending with the Six Nations land reclamation in Ontario in 2006. Gord Hill spent two years unearthing images and researching historical information to create The 500 Years of Resistance Comic Book, which presents the story of Aboriginal resistance in a far-reaching format.

Other events depicted include the 1680 Pueblo Revolt in New Mexico; the Inca insurgency in Peru from the 1500s to the 1780s; Pontiac and the 1763 Rebellion & Royal Proclamation; Geronimo and the 1860s Seminole Wars; Crazy Horse and the 1877 War on the Plains; the rise of the American Indian Movement in the 1960s; 1973's Wounded Knee; the Mohawk Oka Crisis in Quebec in 1990; and the 1995 Aazhoodena/Stoney Point resistance.

With strong, plain language and evocative illustrations, The 500 Years of Resistance Comic Book documents the fighting spirit and ongoing resistance of Indigenous peoples through 500 years of genocide, massacres, torture, rape, displacement, and assimilation: a necessary antidote to the conventional history of the Americas.

The book includes an introduction by Ward Churchill, a writer, political activist, and co-director of the American Indian Movement of Colorado.